Most studies on the relation between serum P and pregnancy outcome are retrospective ( Yovich et al., 2015 Alsbjerg et al., 2018 Cédrin-Durnerin et al., 2019 Gaggiotti-Marre et al., 2019) except one published by our group ( Labarta et al., 2017), which analyzed the relationship between serum P levels on the day of ET and ongoing pregnancy rate (OPR). There is likely a minimum serum P concentration below which ET success rates are significantly lower when using natural micronized vaginal P (MVP) in artificial endometrial preparation cycles. vaginal or subcutaneous) are instead chosen based on patient and doctor preferences ( Vaisbuch et al., 2014). While estrogen administration is tailored to patient need ( Labarta et al., 2017), the same progesterone (P) dose is given to all patients without individualization of luteal phase support (LPS) since an optimal P exposure before embryo transfer (ET) has not been well established ( van de Vijver et al., 2016). However, there is insufficient evidence to recommend any one protocol for endometrial preparation ( Ghobara et al., 2017) and there are no clear guidelines for HRT.
Artificial cycle, serum progesterone, hormonal replacement therapy, pregnancy outcome, luteal phase support IntroductionĪrtificial endometrial preparation with HRT is frequently used for frozen embryo transfer (FET) and egg donation cycles ( Groenewoud et al., 2018).
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